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 Previous Article

Infection and Immunity, September 2004, p. 5530-5533, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5530-5533.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Bordetella pertussis Adenylate Cyclase-Hemolysin Induces Interleukin-6 Secretion by Human Tracheal Epithelial Cells

Laurence Bassinet,1,2 Catherine Fitting,3 Bruno Housset,2 Jean-Marc Cavaillon,3 and Nicole Guiso1*

Unité Prévention et Thérapie Moléculaires des Maladies Humaines,1 Unité Postulante Cytokines & Inflammation, Institut PasteurParis,3 Centre Hospitalier Intercommunal Créteil, Service de Pneumologie, Creteil, France2

Received 3 March 2004/ Returned for modification 19 April 2004/ Accepted 10 May 2004

After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium.

* Corresponding author. Mailing address: Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Ecosystems and Epidemiology of Infectious Diseases Department, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 45 68 83 34. Fax: 33 1 40 61 35 33. E-mail: nguiso{at}pasteur.fr.

Editor: J. D. Clements

Infection and Immunity, September 2004, p. 5530-5533, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5530-5533.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fiser, R., Masin, J., Basler, M., Krusek, J., Spulakova, V., Konopasek, I., Sebo, P. (2007). Third Activity of Bordetella Adenylate Cyclase (AC) Toxin-Hemolysin: MEMBRANE TRANSLOCATION OF AC DOMAIN POLYPEPTIDE PROMOTES CALCIUM INFLUX INTO CD11b+ MONOCYTES INDEPENDENTLY OF THE CATALYTIC AND HEMOLYTIC ACTIVITIES. J. Biol. Chem. 282: 2808-2820 [Abstract] [Full Text]  
  • Lopez-Boado, Y. S., Cobb, L. M., Deora, R. (2005). Bordetella bronchiseptica Flagellin Is a Proinflammatory Determinant for Airway Epithelial Cells. Infect. Immun. 73: 7525-7534 [Abstract] [Full Text]  


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