IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bassinet, L.
Right arrow Articles by Guiso, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bassinet, L.
Right arrow Articles by Guiso, N.

 Previous Article

Infection and Immunity, September 2004, p. 5530-5533, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5530-5533.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Bordetella pertussis Adenylate Cyclase-Hemolysin Induces Interleukin-6 Secretion by Human Tracheal Epithelial Cells

Laurence Bassinet,1,2 Catherine Fitting,3 Bruno Housset,2 Jean-Marc Cavaillon,3 and Nicole Guiso1*

Unité Prévention et Thérapie Moléculaires des Maladies Humaines,1 Unité Postulante Cytokines & Inflammation, Institut PasteurParis,3 Centre Hospitalier Intercommunal Créteil, Service de Pneumologie, Creteil, France2

Received 3 March 2004/ Returned for modification 19 April 2004/ Accepted 10 May 2004

After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium.

* Corresponding author. Mailing address: Unité Prévention et Thérapie Moléculaires des Maladies Humaines, Ecosystems and Epidemiology of Infectious Diseases Department, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 45 68 83 34. Fax: 33 1 40 61 35 33. E-mail: nguiso{at}pasteur.fr.

Editor: J. D. Clements

Infection and Immunity, September 2004, p. 5530-5533, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5530-5533.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2004 by the American Society for Microbiology. All rights reserved.