This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Balloy, V. Articles by Chignard, M. Search for Related Content PubMed PubMed Citation Articles by Balloy, V. Articles by Chignard, M.

 Previous Article  |  Next Article 

Infection and Immunity, January 2005, p. 494-503, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.494-503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis

Unité de Défense Innée et Inflammation, INSERM E336,¹ Unité de Recherche et d'Expertise Histotechnologie et Pathologie,² Unité des Aspergillus, Institut Pasteur, Paris, France³

Received 18 March 2004/ Returned for modification 19 April 2004/ Accepted 10 September 2004

Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of the most life-threatening opportunistic infections in immunocompromised patients. The type of immunosuppressive regimen under which IPA occurs has rarely been investigated. In this study, we evaluated various parameters of the innate immune response during the progression of murine IPA induced by the intratracheal administration of A. fumigatus conidia as a function of two immunosuppressive treatments: a corticosteroid and a chemotherapeutic agent. We compared host responses various times after infection in terms of survival, pulmonary production of pro- and anti-inflammatory cytokines, cellular trafficking in the airways, lung injury, respiratory distress, and fungal development. We found that IPA pathogenesis involved predominantly fungal development in mice treated by chemotherapy and an adverse host response in mice treated with a corticosteroid. These previously unrecognized differences should be taken into account in evaluations of the pathogenesis of IPA in animal models.

Editor: T. R. Kozel

This article has been cited by other articles:

• Lewis, R. E., Albert, N. D., Kontoyiannis, D. P. (2008). Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis. J Antimicrob Chemother 61: 1140-1144 [Abstract] [Full Text]  
• Samarakoon, P., Soubani, A. (2008). Invasive pulmonary aspergillosis in patients with COPD: a report of five cases and systematic review of the literature. Chronic Respiratory Disease 5: 19-27 [Abstract]  
• Hohl, T. M., Feldmesser, M. (2007). Aspergillus fumigatus: Principles of Pathogenesis and Host Defense. Eukaryot Cell 6: 1953-1963 [Full Text]  
• Bulpa, P., Dive, A., Sibille, Y. (2007). Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease. Eur Respir J 30: 782-800 [Abstract] [Full Text]  
• Orciuolo, E., Stanzani, M., Canestraro, M., Galimberti, S., Carulli, G., Lewis, R., Petrini, M., Komanduri, K. V. (2007). Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: implications for the pathogenesis of invasive aspergillosis. J. Leukoc. Biol. 82: 839-848 [Abstract] [Full Text]  
• Sugui, J. A., Pardo, J., Chang, Y. C., Zarember, K. A., Nardone, G., Galvez, E. M., Mullbacher, A., Gallin, J. I., Simon, M. M., Kwon-Chung, K. J. (2007). Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone. Eukaryot Cell 6: 1562-1569 [Abstract] [Full Text]  
• Lewis, R. E., Liao, G., Hou, J., Chamilos, G., Prince, R. A., Kontoyiannis, D. P. (2007). Comparative Analysis of Amphotericin B Lipid Complex and Liposomal Amphotericin B Kinetics of Lung Accumulation and Fungal Clearance in a Murine Model of Acute Invasive Pulmonary Aspergillosis. Antimicrob. Agents Chemother. 51: 1253-1258 [Abstract] [Full Text]  
• Schobel, F., Ibrahim-Granet, O., Ave, P., Latge, J.-P., Brakhage, A. A., Brock, M. (2007). Aspergillus fumigatus Does Not Require Fatty Acid Metabolism via Isocitrate Lyase for Development of Invasive Aspergillosis. Infect. Immun. 75: 1237-1244 [Abstract] [Full Text]  
• Lewis, R. E., Chamilos, G., Prince, R. A., Kontoyiannis, D. P. (2007). Pretreatment with Empty Liposomes Attenuates the Immunopathology of Invasive Pulmonary Aspergillosis in Corticosteroid-Immunosuppressed Mice. Antimicrob. Agents Chemother. 51: 1078-1081 [Abstract] [Full Text]  
• Feldmesser, M. (2006). Role of Neutrophils in Invasive Aspergillosis{triangledown}. Infect. Immun. 74: 6514-6516 [Full Text]  
• Dubourdeau, M., Athman, R., Balloy, V., Huerre, M., Chignard, M., Philpott, D. J., Latge, J.-P., Ibrahim-Granet, O. (2006). Aspergillus fumigatus Induces Innate Immune Responses in Alveolar Macrophages through the MAPK Pathway Independently of TLR2 and TLR4. J. Immunol. 177: 3994-4001 [Abstract] [Full Text]  
• Dennis, C. G., Greco, W. R., Brun, Y., Youn, R., Slocum, H. K., Bernacki, R. J., Lewis, R., Wiederhold, N., Holland, S. M., Petraitiene, R., Walsh, T. J., Segal, B. H. (2006). Effect of Amphotericin B and Micafungin Combination on Survival, Histopathology, and Fungal Burden in Experimental Aspergillosis in the p47phox-/- Mouse Model of Chronic Granulomatous Disease. Antimicrob. Agents Chemother. 50: 422-427 [Abstract] [Full Text]  
• Ellis, M., al-Ramadi, B., Hedstrom, U., Alizadeh, H., Shammas, V., Kristensen, J. (2005). Invasive fungal infections are associated with severe depletion of circulating RANTES. J Med Microbiol 54: 1017-1022 [Abstract] [Full Text]  
• Ramphal, R., Balloy, V., Huerre, M., Si-Tahar, M., Chignard, M. (2005). TLRs 2 and 4 Are Not Involved in Hypersusceptibility to Acute Pseudomonas aeruginosa Lung Infections. J. Immunol. 175: 3927-3934 [Abstract] [Full Text]  
• Balloy, V., Si-Tahar, M., Takeuchi, O., Philippe, B., Nahori, M.-A., Tanguy, M., Huerre, M., Akira, S., Latge, J.-P., Chignard, M. (2005). Involvement of Toll-Like Receptor 2 in Experimental Invasive Pulmonary Aspergillosis. Infect. Immun. 73: 5420-5425 [Abstract] [Full Text]