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Infection and Immunity, January 2005, p. 494-503, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.494-503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis

Viviane Balloy,1 Michel Huerre,2 Jean-Paul Latgé,3 and Michel Chignard1*

Unité de Défense Innée et Inflammation, INSERM E336,1 Unité de Recherche et d'Expertise Histotechnologie et Pathologie,2 Unité des Aspergillus, Institut Pasteur, Paris, France3

Received 18 March 2004/ Returned for modification 19 April 2004/ Accepted 10 September 2004

Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of the most life-threatening opportunistic infections in immunocompromised patients. The type of immunosuppressive regimen under which IPA occurs has rarely been investigated. In this study, we evaluated various parameters of the innate immune response during the progression of murine IPA induced by the intratracheal administration of A. fumigatus conidia as a function of two immunosuppressive treatments: a corticosteroid and a chemotherapeutic agent. We compared host responses various times after infection in terms of survival, pulmonary production of pro- and anti-inflammatory cytokines, cellular trafficking in the airways, lung injury, respiratory distress, and fungal development. We found that IPA pathogenesis involved predominantly fungal development in mice treated by chemotherapy and an adverse host response in mice treated with a corticosteroid. These previously unrecognized differences should be taken into account in evaluations of the pathogenesis of IPA in animal models.

* Corresponding author. Mailing address: Unité de Défense Innée et Inflammation, INSERM E336, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris, France. Phone: (33-1) 45 68 86 88. Fax: (33-1) 45 68 87 03. E-mail: chignard{at}pasteur.fr.

Editor: T. R. Kozel

Infection and Immunity, January 2005, p. 494-503, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.494-503.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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