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Infection and Immunity, January 2005, p. 612-616, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.612-616.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Shiga-Toxigenic Escherichia coli-Inoculated Neonatal Piglets Develop Kidney Lesions That Are Comparable to Those in Humans with Hemolytic-Uremic Syndrome

J. F. Pohlenz,1 K. R. Winter,2 and E. A. Dean-Nystrom1*

Pre-Harvest Food Safety and Enteric Diseases Research Unit, National Animal Disease Center, USDA Agricultural Research Service,1 Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa2

Received 25 June 2004/ Returned for modification 29 July 2004/ Accepted 20 September 2004

Kidney lesions similar to those in humans with hemolytic-uremic syndrome were observed histologically in 82 of 122 piglets inoculated intragastrically with Shiga-toxigenic Escherichia coli but not in 29 controls. The locations of lesions matched locations where Stx-2 binding and Gb3 (globotriasylceramide receptors for Stx) were identified immunohistochemically.

* Corresponding author. Mailing address: National Animal Disease Center, USDA, ARS, P.O. Box 70, Ames, IA 50010-0070. Phone: (515) 663-7376. Fax: (515) 663-7458. E-mail: enystrom{at}nadc.ars.usda.gov.

Editor: J. T. Barbieri

Infection and Immunity, January 2005, p. 612-616, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.612-616.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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