Previous Article | Next Article 
Infection and Immunity, January 2005, p. 617-621, Vol. 73, No. 1
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.1.617-621.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection
Michelle N. Kelly,1
Jay K. Kolls,2
Kyle Happel,3
Joseph D. Schwartzman,4
Paul Schwarzenberger,5
Crescent Combe,1
Magali Moretto,1 and
Imtiaz A. Khan1*
Department of Microbiology, Immunology and Parasitology,1
Department of Pulmonary Medicine,3
Division of Gene Therapy, Louisiana State University Health Sciences Center, New Orleans, Louisiana,5
Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania,2
Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire4
Received 15 April 2004/
Returned for modification 7 June 2004/
Accepted 8 September 2004
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R/ mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
* Corresponding author. Mailing address: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112. Phone: (504) 568-6116. Fax: (504) 568-2918. E-mail:
ikhan{at}lsuhsc.edu.
Editor: S. H. E. Kaufmann
Infection and Immunity, January 2005, p. 617-621, Vol. 73, No. 1
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.1.617-621.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
von Vietinghoff, S., Ley, K.
(2009). IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice. J. Immunol.
183: 865-873
[Abstract]
[Full Text]
-
He, D., Wu, L., Kim, H. K., Li, H., Elmets, C. A., Xu, H.
(2009). IL-17 and IFN-{gamma} Mediate the Elicitation of Contact Hypersensitivity Responses by Different Mechanisms and Both Are Required for Optimal Responses. J. Immunol.
183: 1463-1470
[Abstract]
[Full Text]
-
Freitas, A., Alves-Filho, J. C., Victoni, T., Secher, T., Lemos, H. P., Sonego, F., Cunha, F. Q., Ryffel, B.
(2009). IL-17 Receptor Signaling Is Required to Control Polymicrobial Sepsis. J. Immunol.
182: 7846-7854
[Abstract]
[Full Text]
-
Ben-Sasson, S. Z., Hu-Li, J., Quiel, J., Cauchetaux, S., Ratner, M., Shapira, I., Dinarello, C. A., Paul, W. E.
(2009). IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. USA
106: 7119-7124
[Abstract]
[Full Text]
-
Gigley, J. P., Fox, B. A., Bzik, D. J.
(2009). Cell-Mediated Immunity to Toxoplasma gondii Develops Primarily by Local Th1 Host Immune Responses in the Absence of Parasite Replication. J. Immunol.
182: 1069-1078
[Abstract]
[Full Text]
-
Schulz, S. M., Kohler, G., Schutze, N., Knauer, J., Straubinger, R. K., Chackerian, A. A., Witte, E., Wolk, K., Sabat, R., Iwakura, Y., Holscher, C., Muller, U., Kastelein, R. A., Alber, G.
(2008). Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17. J. Immunol.
181: 7891-7901
[Abstract]
[Full Text]
-
von Vietinghoff, S., Ley, K.
(2008). Homeostatic Regulation of Blood Neutrophil Counts. J. Immunol.
181: 5183-5188
[Abstract]
[Full Text]
-
Gaffen, S.L., Hajishengallis, G.
(2008). A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17. JDR
87: 817-828
[Abstract]
[Full Text]
-
Yu, J. J., Ruddy, M. J., Conti, H. R., Boonanantanasarn, K., Gaffen, S. L.
(2008). The Interleukin-17 Receptor Plays a Gender-Dependent Role in Host Protection against Porphyromonas gingivalis-Induced Periodontal Bone Loss. Infect. Immun.
76: 4206-4213
[Abstract]
[Full Text]
-
Schulz, S. M., Kohler, G., Holscher, C., Iwakura, Y., Alber, G.
(2008). IL-17A is produced by Th17, {gamma}{delta} T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. Int Immunol
20: 1129-1138
[Abstract]
[Full Text]
-
Smith, E., Stark, M. A., Zarbock, A., Burcin, T. L., Bruce, A. C., Vaswani, D., Foley, P., Ley, K.
(2008). IL-17A Inhibits the Expansion of IL-17A-Producing T Cells in Mice through "Short-Loop" Inhibition via IL-17 Receptor. J. Immunol.
181: 1357-1364
[Abstract]
[Full Text]
-
Molesworth-Kenyon, S. J., Yin, R., Oakes, J. E., Lausch, R. N.
(2008). IL-17 receptor signaling influences virus-induced corneal inflammation. J. Leukoc. Biol.
83: 401-408
[Abstract]
[Full Text]
-
Sukhumavasi, W., Egan, C. E., Denkers, E. Y.
(2007). Mouse Neutrophils Require JNK2 MAPK for Toxoplasma gondii-Induced IL-12p40 and CCL2/MCP-1 Release. J. Immunol.
179: 3570-3577
[Abstract]
[Full Text]
-
Ebensen, T., Schulze, K., Riese, P., Morr, M., Guzman, C. A.
(2007). The Bacterial Second Messenger cdiGMP Exhibits Promising Activity as a Mucosal Adjuvant. CVI
14: 952-958
[Abstract]
[Full Text]
-
Maitra, A., Shen, F., Hanel, W., Mossman, K., Tocker, J., Swart, D., Gaffen, S. L.
(2007). Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc. Natl. Acad. Sci. USA
104: 7506-7511
[Abstract]
[Full Text]
-
Yu, J. J., Ruddy, M. J., Wong, G. C., Sfintescu, C., Baker, P. J., Smith, J. B., Evans, R. T., Gaffen, S. L.
(2007). An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood
109: 3794-3802
[Abstract]
[Full Text]
-
Higgins, S. C., Jarnicki, A. G., Lavelle, E. C., Mills, K. H. G.
(2006). TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells. J. Immunol.
177: 7980-7989
[Abstract]
[Full Text]
-
Schnyder-Candrian, S., Togbe, D., Couillin, I., Mercier, I., Brombacher, F., Quesniaux, V., Fossiez, F., Ryffel, B., Schnyder, B.
(2006). Interleukin-17 is a negative regulator of established allergic asthma. JEM
203: 2715-2725
[Abstract]
[Full Text]
-
He, D., Wu, L., Kim, H. K., Li, H., Elmets, C. A., Xu, H.
(2006). CD8+ IL-17-Producing T Cells Are Important in Effector Functions for the Elicitation of Contact Hypersensitivity Responses. J. Immunol.
177: 6852-6858
[Abstract]
[Full Text]
-
Siciliano, N. A., Skinner, J. A., Yuk, M. H.
(2006). Bordetella bronchiseptica Modulates Macrophage Phenotype Leading to the Inhibition of CD4+ T Cell Proliferation and the Initiation of a Th17 Immune Response. J. Immunol.
177: 7131-7138
[Abstract]
[Full Text]
-
Shen, F., Hu, Z., Goswami, J., Gaffen, S. L.
(2006). Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes. J. Biol. Chem.
281: 24138-24148
[Abstract]
[Full Text]
-
Keller, C., Hoffmann, R., Lang, R., Brandau, S., Hermann, C., Ehlers, S.
(2006). Genetically Determined Susceptibility to Tuberculosis in Mice Causally Involves Accelerated and Enhanced Recruitment of Granulocytes. Infect. Immun.
74: 4295-4309
[Abstract]
[Full Text]
-
Kramer, J. M., Yi, L., Shen, F., Maitra, A., Jiao, X., Jin, T., Gaffen, S. L.
(2006). Cutting Edge: Evidence for Ligand-Independent Multimerization of the IL-17 Receptor. J. Immunol.
176: 711-715
[Abstract]
[Full Text]