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Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

Department of Microbiology, Immunology and Parasitology,¹ Department of Pulmonary Medicine,³ Division of Gene Therapy, Louisiana State University Health Sciences Center, New Orleans, Louisiana,⁵ Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania,² Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire⁴

Received 15 April 2004/ Returned for modification 7 June 2004/ Accepted 8 September 2004

We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R^–/– mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

Editor: S. H. E. Kaufmann

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