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Infection and Immunity, January 2005, p. 617-621, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.617-621.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

Michelle N. Kelly,1 Jay K. Kolls,2 Kyle Happel,3 Joseph D. Schwartzman,4 Paul Schwarzenberger,5 Crescent Combe,1 Magali Moretto,1 and Imtiaz A. Khan1*

Department of Microbiology, Immunology and Parasitology,1 Department of Pulmonary Medicine,3 Division of Gene Therapy, Louisiana State University Health Sciences Center, New Orleans, Louisiana,5 Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania,2 Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire4

Received 15 April 2004/ Returned for modification 7 June 2004/ Accepted 8 September 2004

We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R–/– mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112. Phone: (504) 568-6116. Fax: (504) 568-2918. E-mail: ikhan{at}lsuhsc.edu.

Editor: S. H. E. Kaufmann

Infection and Immunity, January 2005, p. 617-621, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.617-621.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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