This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Egusa, H. Articles by Hamada, T. Search for Related Content PubMed PubMed Citation Articles by Egusa, H. Articles by Hamada, T.

Intercellular Adhesion Molecule 1-Dependent Activation of Interleukin 8 Expression in Candida albicans-Infected Human Gingival Epithelial Cells

Department of Prosthetic Dentistry, Hiroshima University Graduate School of Biomedical Sciences, Minami-ku, Hiroshima City,¹ Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, Suita City, Osaka, Japan,² The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, California³

Received 25 August 2004/ Returned for modification 31 August 2004/ Accepted 10 September 2004

Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.

Editor: T. R. Kozel