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Infection and Immunity, January 2005, p. 632-634, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.632-634.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Chlamydia pneumoniae Enhances Cytokine-Stimulated Human Monocyte Matrix Metalloproteinases through a Prostaglandin E2-Dependent Mechanism

Min P. Kim,1 Charlotte A. Gaydos,2 Billie Jo Wood,2 Justin P. Hardick,2 Yahong Zhang,1 and Larry M. Wahl1*

National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda,1 Johns Hopkins University School of Medicine, Baltimore, Maryland2

Received 25 March 2004/ Returned for modification 12 May 2004/ Accepted 21 September 2004

Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C. pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E2. These findings may have implications for atherosclerotic plaque rupture.

* Corresponding author. Mailing address: Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Dr., Building 30, Room 325, Bethesda, MD 20892-4352. Phone: (301) 496-9219. Fax: (301) 402-1064. E-mail: lwahl{at}dir.nidcr.nih.gov.

Editor: J. B. Bliska

Infection and Immunity, January 2005, p. 632-634, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.632-634.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yen, J.-H., Khayrullina, T., Ganea, D. (2008). PGE2-induced metalloproteinase-9 is essential for dendritic cell migration. Blood 111: 260-270 [Abstract] [Full Text]  
  • Kim, M. P., Zhou, M., Wahl, L. M. (2005). Angiotensin II increases human monocyte matrix metalloproteinase-1 through the AT2 receptor and prostaglandin E2: implications for atherosclerotic plaque rupture. J. Leukoc. Biol. 78: 195-201 [Abstract] [Full Text]  


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