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Infection and Immunity, January 2005, p. 635-637, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.635-637.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Detection of Gliotoxin in Experimental and Human Aspergillosis

Russell E. Lewis,1,2* Nathan P. Wiederhold,1,2 Jingduan Chi,1 Xiang Y. Han,2 Krishna V. Komanduri,2 Dimitrios P. Kontoyiannis,1,2 and Randall A. Prince1,2

University of Houston College of Pharmacy,1 The University of Texas M. D. Anderson Cancer Center, Houston, Texas2

Received 20 June 2004/ Returned for modification 2 August 2004/ Accepted 31 August 2004

Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

* Corresponding author. Mailing address: University of Houston College of Pharmacy; 1441 Moursund St. #423, Houston, TX 77030. Phone: (713) 795-8326. Fax: (713) 795-8383. E-mail: rlewis{at}uh.edu.

Editor: T. R. Kozel

Infection and Immunity, January 2005, p. 635-637, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.635-637.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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