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Detection of Gliotoxin in Experimental and Human Aspergillosis

University of Houston College of Pharmacy,¹ The University of Texas M. D. Anderson Cancer Center, Houston, Texas²

Received 20 June 2004/ Returned for modification 2 August 2004/ Accepted 31 August 2004

Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Editor: T. R. Kozel

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