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Infection and Immunity, January 2005, p. 644-648, Vol. 73, No. 1
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.1.644-648.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Truncated Internalin A and Asymptomatic Listeria monocytogenes Carriage: In Vivo Investigation by Allelic Exchange

Maïwenn Olier, Dominique Garmyn,^* Sandrine Rousseaux, Jean-Paul Lemaître, Pascal Piveteau, and Jean Guzzo

Laboratoire de Microbiologie, UMR INRA 1232, Université de Bourgogne, Dijon, France

Received 4 August 2004/ Returned for modification 14 September 2004/ Accepted 23 September 2004

Allelic exchange of the region coding for the C terminus of InlA between one epidemic (with an 80-kDa InlA) and one asymptomatic (with a 47-kDa InlA) carriage Listeria monocytogenes strain confirmed the need for this region for internalin entry in vitro. Interestingly, restoration of internalin A functionality did not result in full virulence in chicken embryo assays.

Editor: A. D. O'Brien

Present address: Laboratoire de Pathologie Infectieuse et Immunologie, INRA, 37380 Nouzilly, France.

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