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Infection and Immunity, October 2005, p. 6846-6851, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.6846-6851.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antibody Profiles Characteristic of Mycobacterium tuberculosis Infection State

Amy Davidow,1 Ganga V. Kanaujia,2 Lanbo Shi,2 Justin Kaviar,2,3 XuDong Guo,2 Nackmoon Sung,2 Gilla Kaplan,2 Dick Menzies,4,5 and Maria L. Gennaro2*

University of Medicine and Dentistry of New Jersey, Newark, New Jersey,1 Public Health Research Institute, Newark, New Jersey,2 The Collegiate School, New York, New York,3 McGill University,4 Montreal Chest Clinic, Montreal, Quebec, Canada5

Received 14 April 2005/ Returned for modification 31 May 2005/ Accepted 17 June 2005

The relationship between specific antibody profiles and tuberculosis (TB) state was investigated by measuring serum antibody levels to six Mycobacterium tuberculosis antigens in human subjects grouped into four diagnostic categories: active disease, inactive (past) tuberculosis, latent infection without radiographic chest abnormalities, and infection free. Statistical data analyses showed that the latter two groups were serologically indistinguishable and that active tuberculosis and inactive tuberculosis were characterized by different antibody profiles. Antibodies to the 38-kDa antigen, alanine dehydrogenase, and Rv2626c were associated with active TB, while antibodies to the 16-kDa antigen, ferredoxin A, and ESAT-6 were associated with inactive TB. Thus, the targets of the immune response vary with tuberculosis state. The correlation between bacterial antigen production and infection stage was investigated in mice infected with M. tuberculosis by bacterial transcription profiling. It was found that levels of transcripts encoding the six M. tuberculosis antigens varied during infection. Together, the data indicate that antigen composition of tubercle bacilli varies with stage of infection and that immunoprofiling can distinguish between tuberculosis states.

* Corresponding author. Mailing address: Public Health Research Institute, Room W250G, 225 Warren Street, Newark, NJ 07103. Phone: (973) 854-3210. Fax: (973) 854-3101. E-mail: gennaro{at}phri.org.

Editor: J. D. Clements

Infection and Immunity, October 2005, p. 6846-6851, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.6846-6851.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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