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Infection and Immunity, October 2005, p. 7006-7010, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7006-7010.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pathophysiological Manifestations in Mice Exposed to Anthrax Lethal Toxin

Nathan C. Culley,1* David M. Pinson,1 Anuradha Chakrabarty,2 Matthew S. Mayo,3 and Steven M. LeVine2

Lab Animal Resources,1 Department of Molecular and Integrative Physiology,2 Department of Preventative Medicine and Public Health, University of Kansas Medical Center, Kansas City, Kansas 661603

Received 8 March 2005/ Returned for modification 27 April 2005/ Accepted 19 June 2005

Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.

* Corresponding author. Mailing address: Mail Stop 1031, 3901 Rainbow Boulevard, KU Medical Center, Kansas City, KS 66160. Phone: (913) 588-7352. Fax: (913) 588-7277. E-mail: nculley{at}kumc.edu.

Editor: J. T. Barbieri

Infection and Immunity, October 2005, p. 7006-7010, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7006-7010.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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