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Infection and Immunity, October 2005, p. 7011-7013, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7011-7013.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Role of B Cells in Vaccine-Induced Immunity against Coccidioidomycosis

D. Mitchell Magee,1* Rhonda L. Friedberg,1 Melanie D. Woitaske,2 Stephen Albert Johnston,1 and Rebecca A. Cox2

Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8573,1 Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 782292

Received 24 November 2004/ Returned for modification 13 January 2005/ Accepted 12 May 2005

We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice.

* Corresponding author. Present address: Center for Innovations in Medicine, Biodesign Institute, Arizona State University, P.O. Box 875001, Tempe, AZ 85287-5001. Phone: (214) 648-4993. Fax: (214) 648-4156. E-mail: mitch.magee{at}asu.edu.

Editor: T. R. Kozel

Infection and Immunity, October 2005, p. 7011-7013, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7011-7013.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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