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Identification of Actinobacillus suis Genes Essential for the Colonization of the Upper Respiratory Tract of Swine

University of Guelph, Ontario N1G 2W1, Canada,¹ Université du Québec à Trois-Rivières, Trois-Rivières, Québec G9A 5H7, Canada²

Received 5 April 2005/ Returned for modification 10 June 2005/ Accepted 29 June 2005

Actinobacillus suis has emerged as an important opportunistic pathogen of high-health-status swine. A colonization challenge method was developed, and using PCR-based signature-tagged transposon mutagenesis, 13 genes belonging to 9 different functional classes were identified that were necessary for A. suis colonization of the upper respiratory tract of swine.

Editor: A. D. O'Brien

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