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Infection and Immunity, October 2005, p. 7040-7042, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7040-7042.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Protective Role of Neutrophils in Mice Experimentally Infected with Rhodococcus equi

Ronald J. Martens,1* Noah D. Cohen,1 Samuel L. Jones,3 Thomas A. Moore,4 and John F. Edwards2

Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences,1 Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas,2 Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina,3 Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan4

Received 17 March 2005/ Returned for modification 20 April 2005/ Accepted 31 May 2005

Neutrophils are important in controlling early infections with the intracellular bacterium Rhodococcus equi. Antineutrophil monoclonal antibody (RB6-8C5)-induced neutrophil deficiency during the first week after experimental infection of mice with R. equi resulted in more severe disease and significantly increased tissue concentrations of R. equi.

* Corresonding author. Mailing address: Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843. Phone: (979) 845-1682. Fax: (979) 847-8863. E-mail: rmartens{at}cvm.tamu.edu.

Editor: J. B. Bliska

Infection and Immunity, October 2005, p. 7040-7042, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7040-7042.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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