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Infection and Immunity, October 2005, p. 7043-7046, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7043-7046.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antibodies to Conserved Pneumococcal Antigens Correlate with, but Are Not Required for, Protection against Pneumococcal Colonization Induced by Prior Exposure in a Mouse Model

Krzysztof Trzcinski,1 Claudette Thompson,1 Richard Malley,2 and Marc Lipsitch1*

Departments of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115,1 Division of Infectious Diseases, Department of Medicine, Children's Hospital, Boston, Massachusetts 021152

Received 22 March 2005/ Returned for modification 20 May 2005/ Accepted 3 June 2005

In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

* Corresponding author. Mailing address: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115. Phone: (617) 432-4559. Fax: (617) 566-7805. E-mail: MLIPSITC{at}HSPH.HARVARD.EDU.

Editor: J. N. Weiser

Infection and Immunity, October 2005, p. 7043-7046, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7043-7046.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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