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Infection and Immunity, October 2005, p. 7047-7050, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7047-7050.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Relationship of Virulence Factor Expression to Evolved Virulence in Mouse-Passaged Cryptococcus neoformans Lines

Erin E. McClelland,1* Wesley T. Perrine,2 Wayne K. Potts,2 and Arturo Casadevall1

Department of Medicine, 702 Golding, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461,1 Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 841122

Received 11 March 2005/ Returned for modification 25 April 2005/ Accepted 27 May 2005

Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of virulence remain to be discovered.

* Corresponding author. Mailing address: Department of Medicine, 702 Golding, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: (718) 430-3768. Fax: (718) 430-8701. E-mail: mcclella{at}aecom.yu.edu.

Editor: T. R. Kozel

Infection and Immunity, October 2005, p. 7047-7050, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7047-7050.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Litvintseva, A. P., Mitchell, T. G. (2009). Most Environmental Isolates of Cryptococcus neoformans var. grubii (Serotype A) Are Not Lethal for Mice. Infect. Immun. 77: 3188-3195 [Abstract] [Full Text]  
  • McClelland, E. E., Bernhardt, P., Casadevall, A. (2006). Estimating the Relative Contributions of Virulence Factors for Pathogenic Microbes. Infect. Immun. 74: 1500-1504 [Abstract] [Full Text]  


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