This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukasawa, Y.
Right arrow Articles by Mitsuyama, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukasawa, Y.
Right arrow Articles by Mitsuyama, M.

 Previous Article  |  Next Article 

Infection and Immunity, October 2005, p. 7051-7055, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7051-7055.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Streptomycin-Dependent Exhibition of Cytokine-Inducing Activity in Streptomycin-Dependent Mycobacterium tuberculosis Strain 18b

Yutaka Fukasawa,1,3 Ikuo Kawamura,1 Ryosuke Uchiyama,1 Kazuhiro Yamamoto,1 Taijin Kaku,1 Takanari Tominaga,1 Takamasa Nomura,1 Satoshi Ichiyama,2 Takayuki Ezaki,3 and Masao Mitsuyama1*

Department of Microbiology,1 Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto,2 Department of Microbiology, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan3

Received 24 February 2005/ Returned for modification 12 April 2005/ Accepted 13 June 2005

Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.

* Corresponding author. Mailing address: Department of Microbiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. Phone: 81-75-753-4448. Fax: 81-75-753-4446. E-mail: mituyama{at}mb.med.kyoto-u.ac.jp.

Editor: J. L. Flynn

Infection and Immunity, October 2005, p. 7051-7055, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7051-7055.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kurenuma, T., Kawamura, I., Hara, H., Uchiyama, R., Daim, S., Dewamitta, S. R., Sakai, S., Tsuchiya, K., Nomura, T., Mitsuyama, M. (2009). The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages. Infect. Immun. 77: 3992-4001 [Abstract] [Full Text]  
  • Hara, H., Tsuchiya, K., Nomura, T., Kawamura, I., Shoma, S., Mitsuyama, M. (2008). Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin, Listeriolysin O, after Evasion from Phagosome into the Cytoplasm. J. Immunol. 180: 7859-7868 [Abstract] [Full Text]  
  • Hara, H., Kawamura, I., Nomura, T., Tominaga, T., Tsuchiya, K., Mitsuyama, M. (2007). Cytolysin-Dependent Escape of the Bacterium from the Phagosome Is Required but Not Sufficient for Induction of the Th1 Immune Response against Listeria monocytogenes Infection: Distinct Role of Listeriolysin O Determined by Cytolysin Gene Replacement. Infect. Immun. 75: 3791-3801 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»