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Infection and Immunity, October 2005, p. 7056-7060, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7056-7060.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effects of Dexamethasone and Transient Malnutrition on Rabbits Infected with Aerosolized Mycobacterium tuberculosis CDC1551

Anup K. Kesavan,1 Susana E. Mendez,8 Christine L. Hatem,1 Javier Lopez-Molina,1 Katherine Aird,1 M. Louise M. Pitt,7 Arthur M. Dannenberg Jr,2,4,5,6 and Yukari C. Manabe1,2,3*

Departments of Medicine,1 Pathology, School of Medicine,5 Departments of Molecular Microbiology and Immunology,2 International Health,3 Environmental Health Sciences,4 Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland,6 Department of Aerobiology and Product Evaluation, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland,7 Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, D.C.8

Received 3 May 2005/ Returned for modification 14 June 2005/ Accepted 22 June 2005

Malnutrition is common in the developing world, where tuberculosis is often endemic. Rabbits infected with aerosolized Mycobacterium tuberculosis that subsequently became inadvertently and transiently malnourished had compromised cell-mediated immunity comparable to that of the rabbits immunosuppressed with dexamethasone. They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses.

* Corresponding author. Mailing address: Johns Hopkins University School of Medicine, 1503 E. Jefferson Street, Room 108, Baltimore, MD 21231-1004. Phone: (410) 614-6600. Fax: (410) 614-8173. E-mail: ymanabe{at}jhmi.edu.

Editor: J. L. Flynn

Infection and Immunity, October 2005, p. 7056-7060, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7056-7060.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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