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Infection and Immunity, October 2005, p. 7061-7063, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7061-7063.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Induction of SAP7 Correlates with Virulence in an Intravenous Infection Model of Candidiasis but Not in a Vaginal Infection Model in Mice

Brad N. Taylor, Holger Hannemann, Miriam Sehnal, Antje Biesemeier, Anja Schweizer, Martin Röllinghoff, and Klaus Schröppel*

Institute of Clinical Microbiology, Immunology, and Hygiene, Friedrich-Alexander University Erlangen-Nürnberg, Wasserturmstrasse 3/5, D-91054 Erlangen, Germany

Received 1 July 2004/ Returned for modification 17 August 2004/ Accepted 13 July 2005

SAP7 of Candida albicans is induced after vaginal infection of mice. Conversely, virulence during vaginal infection was not affected in a {Delta}sap7/{Delta}sap7 mutant strain. Only a partial virulence phenotype was detectable after intravenous injection. In conclusion, SAP7 expression does not correlate with C. albicans virulence in mice.

* Corresponding author. Mailing address: Institute of Clinical Microbiology, Immunology, and Hygiene, Friedrich-Alexander University Erlangen-Nürnberg, Wasserturmstraße 3/5, D-91054 Erlangen, Germany. Phone: 49 9131 852 2577. Fax: 49 9131 851 001. E-mail: yeast{at}rzmail.uni-erlangen.de.

Editor: T. R. Kozel

Infection and Immunity, October 2005, p. 7061-7063, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7061-7063.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hornbach, A., Heyken, A., Schild, L., Hube, B., Loffler, J., Kurzai, O. (2009). The Glycosylphosphatidylinositol-Anchored Protease Sap9 Modulates the Interaction of Candida albicans with Human Neutrophils. Infect. Immun. 77: 5216-5224 [Abstract] [Full Text]  
  • Chaffin, W. L. (2008). Candida albicans Cell Wall Proteins. Microbiol. Mol. Biol. Rev. 72: 495-544 [Abstract] [Full Text]  


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