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Infection and Immunity, October 2005, p. 7064-7068, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7064-7068.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mycobacterial Lipomannan Induces Matrix Metalloproteinase-9 Expression in Human Macrophagic Cells through a Toll-Like Receptor 1 (TLR1)/TLR2- and CD14-Dependent Mechanism

Elisabeth Elass,1* Laëtitia Aubry,1 Maryse Masson,1 Agnès Denys,1 Yann Guérardel,1 Emmanuel Maes,1 Dominique Legrand,1 Joël Mazurier,1 and Laurent Kremer2

Unité de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche no. 8576 du Centre National de la Recherche Scientifique, Institut Fédératif de Recherche 118, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq cedex,1 Laboratoire de Dynamique Moléculaire des Interactions Membranaires, UMR CNRS no. 5539, Université des Sciences et Techniques du Languedoc (Montpellier II), 34095 Montpellier Cedex 5, France2

Received 3 November 2004/ Returned for modification 13 December 2004/ Accepted 22 June 2005

Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.

* Corresponding author. Mailing address: Unité de Glycobiologie Structurale et Fonctionnelle, UMR CNRS no. 8576, IFR 118, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq Cedex, France. Phone: 33 3 20 33 72 39. Fax: 33 3 20 43 65 55. E-mail: elisabeth.elass{at}univ-lille1.fr.

Editor: J. L. Flynn

Infection and Immunity, October 2005, p. 7064-7068, Vol. 73, No. 10
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.10.7064-7068.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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