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Infection and Immunity, November 2005, p. 7759-7764, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7759-7764.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Memory T Lymphocytes Generated by Mycobacterium bovis BCG Vaccination Reside within a CD4 CD44lo CD62 Ligandhi Population

Andre Kipnis, Scott Irwin, Angelo A. Izzo, Randall J. Basaraba, and Ian M. Orme*

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 6 June 2005/ Returned for modification 19 July 2005/ Accepted 27 July 2005

In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo (CD62Llo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-5777. Fax: (970) 491-5125. E-mail: Ian.orme{at}colostate.edu.

Editor: J. D. Clements

Infection and Immunity, November 2005, p. 7759-7764, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7759-7764.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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