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Infection and Immunity, November 2005, p. 7759-7764, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7759-7764.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Memory T Lymphocytes Generated by Mycobacterium bovis BCG Vaccination Reside within a CD4 CD44^lo CD62 Ligand^hi Population

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 6 June 2005/ Returned for modification 19 July 2005/ Accepted 27 July 2005

In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44^hi CD62 ligand^lo (CD62L^lo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44^lo CD62L^hi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset.

Editor: J. D. Clements

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