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Infection and Immunity, November 2005, p. 7765-7767, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7765-7767.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Vaginal Epithelial Cell Anti-Candida albicans Activity Is Associated with Protection against Symptomatic Vaginal Candidiasis

Melissa M. Barousse,1 Terri Espinosa,2 Kathleen Dunlap,2 and Paul L. Fidel Jr1*

Department of Microbiology, Immunology, and Parasitology,1 Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, New Orleans, Louisiana2

Received 28 June 2005/ Returned for modification 4 August 2005/ Accepted 15 August 2005

Vaginal epithelial cell (VEC) anti-Candida albicans activity, despite being measured in vitro, is considered an innate host defense mechanism. This was supported further by the fact that women protected from symptomatic infection following a live intravaginal Candida challenge had increased VEC anti-Candida activity compared to those who acquired a symptomatic infection.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112. Phone: (504) 568-4066. Fax: (504) 568-4066. E-mail: pfidel{at}lsuhsc.edu.

Editor: A. Casadevall

Infection and Immunity, November 2005, p. 7765-7767, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7765-7767.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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