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Infection and Immunity, November 2005, p. 7775-7778, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7775-7778.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Immunization with Recombinant Streptococcus pneumoniae Neuraminidase NanA Protects Chinchillas against Nasopharyngeal Colonization

H. H. Tong, D. Li, S. Chen, J. P. Long, and T. F. DeMaria*

Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210

Received 10 May 2005/ Returned for modification 24 June 2005/ Accepted 5 August 2005

Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.

* Corresponding author. Mailing address: Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Room 4331 Cramblett Hall, 456 W. 10th Ave., Columbus, OH 43210. Phone: (614) 293-8103. Fax: (614) 293-5506. E-mail: demaria.2{at}osu.edu.

Editor: J. N. Weiser

Infection and Immunity, November 2005, p. 7775-7778, Vol. 73, No. 11
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.11.7775-7778.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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