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Infection and Immunity, December 2005, p. 8393-8396, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8393-8396.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Impaired Kupffer Cells in Highly Susceptible Mice Infected with Trypanosoma congolense

Meiqing Shi, Guojian Wei, Wanling Pan, and Henry Tabel*

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada

Received 10 June 2005/ Returned for modification 18 July 2005/ Accepted 2 September 2005

In highly susceptible BALB/c mice infected with Trypanosoma congolense, the total number of Kupffer cells in the liver remains constant; however, their mean size increases fivefold towards the terminal stage. About 25% of Kupffer cells undergo apoptosis. We suggest that development of an impairment of the macrophage system might be a major mechanism for inefficient elimination of trypanosomes.

* Corresponding author. Mailing address: Department of Veterinary Microbiology, WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada. Phone: 306-966-7221. Fax: 306-966-7244. E-mail: tabel{at}sask.usask.ca.

Editor: W. A. Petri, Jr.

Infection and Immunity, December 2005, p. 8393-8396, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8393-8396.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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