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Infection and Immunity, December 2005, p. 8397-8401, Vol. 73, No. 12
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.12.8397-8401.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Toll-Like Receptor 2 Deficiency Delays Pneumococcal Phagocytosis and Impairs Oxidative Killing by Granulocytes
Maryse Letiembre,1,
Hakim Echchannaoui,1,
Philipp Bachmann,1
Fabrizia Ferracin,1
Concepción Nieto,2
Manuel Espinosa,2 and
Regine Landmann1*
Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland,1
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, E-28040 Madrid, Spain2
Received 23 July 2005/
Accepted 5 August 2005
Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2/) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2/ PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.
* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland. Phone: 41-61-265 23 25. Fax: 41-61-265 32 72. E-mail:
Regine.Landmann{at}unibas.ch.
Editor: J. N. Weiser
M.L. and H.E. contributed equally to this work.
Infection and Immunity, December 2005, p. 8397-8401, Vol. 73, No. 12
0019-9567/05/$08.00+0 doi:10.1128/IAI.73.12.8397-8401.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.
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