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Infection and Immunity, December 2005, p. 8397-8401, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8397-8401.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Toll-Like Receptor 2 Deficiency Delays Pneumococcal Phagocytosis and Impairs Oxidative Killing by Granulocytes

Maryse Letiembre,1,{dagger} Hakim Echchannaoui,1,{dagger} Philipp Bachmann,1 Fabrizia Ferracin,1 Concepción Nieto,2 Manuel Espinosa,2 and Regine Landmann1*

Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland,1 Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, E-28040 Madrid, Spain2

Received 23 July 2005/ Accepted 5 August 2005

Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2–/–) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2–/– PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH-4031 Basel, Switzerland. Phone: 41-61-265 23 25. Fax: 41-61-265 32 72. E-mail: Regine.Landmann{at}unibas.ch.

Editor: J. N. Weiser

{dagger} M.L. and H.E. contributed equally to this work.

Infection and Immunity, December 2005, p. 8397-8401, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8397-8401.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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