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Infection and Immunity, December 2005, p. 8402-8406, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8402-8406.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis

Kristin J. Carpenter,1 Karen F. Buckland,1 Zhou Xing,2 and Cory M. Hogaboam1*

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109,1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z52

Received 13 May 2005/ Returned for modification 10 June 2005/ Accepted 12 July 2005

Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

* Corresponding author. Mailing address: Department of Pathology, University of Michigan Medical School, Rm. 5216B, Med. Sci. I, 1301 Catherine Road, Ann Arbor, MI 48109-0602. Phone: (734) 936-7854. Fax: (734) 936-7996. E-mail: hogaboam{at}med.umich.edu.

Editor: T. R. Kozel

Infection and Immunity, December 2005, p. 8402-8406, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8402-8406.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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