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Infection and Immunity, December 2005, p. 8402-8406, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8402-8406.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis

Kristin J. Carpenter,1 Karen F. Buckland,1 Zhou Xing,2 and Cory M. Hogaboam1*

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109,1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z52

Received 13 May 2005/ Returned for modification 10 June 2005/ Accepted 12 July 2005

Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

* Corresponding author. Mailing address: Department of Pathology, University of Michigan Medical School, Rm. 5216B, Med. Sci. I, 1301 Catherine Road, Ann Arbor, MI 48109-0602. Phone: (734) 936-7854. Fax: (734) 936-7996. E-mail: hogaboam{at}med.umich.edu.

Editor: T. R. Kozel

Infection and Immunity, December 2005, p. 8402-8406, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8402-8406.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Divangahi, M., Yang, T., Kugathasan, K., McCormick, S., Takenaka, S., Gaschler, G., Ashkar, A., Stampfli, M., Gauldie, J., Bramson, J., Takai, T., Brown, E., Yokoyama, W. M., Aoki, N., Xing, Z. (2007). Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection. J. Immunol. 179: 4015-4026 [Abstract] [Full Text]  


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