This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fernández Miyakawa, M. E.
Right arrow Articles by Ibarra, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fernández Miyakawa, M. E.
Right arrow Articles by Ibarra, C.

 Previous Article  |  Next Article 

Infection and Immunity, December 2005, p. 8407-8410, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8407-8410.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clostridium perfringens Enterotoxin Damages the Human Intestine In Vitro

M. E. Fernández Miyakawa,1* V. Pistone Creydt,2 F. A. Uzal,1 B. A. McClane,3 and C. Ibarra2

California Animal Health and Food Safety Laboratory, University of California—Davis, San Bernardino, California,1 Laboratorio de Fisiopatogenia, Departamento de Fisiología, Universidad de Buenos Aires, Buenos Aires, Argentina,2 Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania3

Received 13 July 2005/ Returned for modification 27 August 2005/ Accepted 7 September 2005

In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant.


* Corresponding author. Mailing address: California Animal Health and Food Safety Laboratory-San Bernardino Branch, University of California—Davis, 105 W. Central Avenue, San Bernardino, CA 92408. Phone: (909) 383-4287. Fax: (909) 884-5980. E-mail: mmiyakaw{at}cahfs.ucdavis.edu.

Editor: J. T. Barbieri


Infection and Immunity, December 2005, p. 8407-8410, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8407-8410.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Harry, K. H., Zhou, R., Kroos, L., Melville, S. B. (2009). Sporulation and Enterotoxin (CPE) Synthesis Are Controlled by the Sporulation-Specific Sigma Factors SigE and SigK in Clostridium perfringens. J. Bacteriol. 191: 2728-2742 [Abstract] [Full Text]  
  • Vidal, J. E., McClane, B. A., Saputo, J., Parker, J., Uzal, F. A. (2008). Effects of Clostridium perfringens Beta-Toxin on the Rabbit Small Intestine and Colon. Infect. Immun. 76: 4396-4404 [Abstract] [Full Text]  
  • Smedley, J. G. III, Saputo, J., Parker, J. C., Fernandez-Miyakawa, M. E., Robertson, S. L., McClane, B. A., Uzal, F. A. (2008). Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity. Infect. Immun. 76: 3793-3800 [Abstract] [Full Text]  
  • Van Itallie, C. M., Betts, L., Smedley, J. G. III, McClane, B. A., Anderson, J. M. (2008). Structure of the Claudin-binding Domain of Clostridium perfringens Enterotoxin. J. Biol. Chem. 283: 268-274 [Abstract] [Full Text]