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Infection and Immunity, December 2005, p. 8407-8410, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8407-8410.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clostridium perfringens Enterotoxin Damages the Human Intestine In Vitro

M. E. Fernández Miyakawa,1* V. Pistone Creydt,2 F. A. Uzal,1 B. A. McClane,3 and C. Ibarra2

California Animal Health and Food Safety Laboratory, University of California—Davis, San Bernardino, California,1 Laboratorio de Fisiopatogenia, Departamento de Fisiología, Universidad de Buenos Aires, Buenos Aires, Argentina,2 Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania3

Received 13 July 2005/ Returned for modification 27 August 2005/ Accepted 7 September 2005

In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant.

* Corresponding author. Mailing address: California Animal Health and Food Safety Laboratory-San Bernardino Branch, University of California—Davis, 105 W. Central Avenue, San Bernardino, CA 92408. Phone: (909) 383-4287. Fax: (909) 884-5980. E-mail: mmiyakaw{at}cahfs.ucdavis.edu.

Editor: J. T. Barbieri

Infection and Immunity, December 2005, p. 8407-8410, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8407-8410.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Smedley, J. G. III, Saputo, J., Parker, J. C., Fernandez-Miyakawa, M. E., Robertson, S. L., McClane, B. A., Uzal, F. A. (2008). Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity. Infect. Immun. 76: 3793-3800 [Abstract] [Full Text]  
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