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Infection and Immunity, December 2005, p. 8418-8424, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8418-8424.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

High Susceptibility of Human Dendritic Cells to Invasion by the Intracellular Pathogens Brucella suis, B. abortus, and B. melitensis

Elisabeth Billard,1 Chantal Cazevieille,2 Jacques Dornand,1 and Antoine Gross1*

INSERM U431, University of Montpellier 2, Place E. Bataillon, 34095 Montpellier, France,1 CRIC/IURC, 641 avenue du Doyen Gaston Giraud, 34093 Montpellier, France2

Received 4 July 2005/ Returned for modification 4 August 2005/ Accepted 16 September 2005

Bacteria from the Brucella genus are able to survive and proliferate within macrophages. Because they are phylogenetically closely related to macrophages, myeloid dendritic cells (DCs) constitute potential targets for Brucella bacteria. Here we report that DCs display a great susceptibility to Brucella infection. Therefore, DCs might serve as a reservoir and be important for the development of Brucella bacteria within their host.

* Corresponding author. Mailing address: INSERM U431, Université Montpellier II, cc100, Place E. Bataillon, 34095 Montpellier, France. Phone: 33 4 67 14 32 09. Fax: 33 4 67 14 33 38. E-mail: gross{at}univ-montp2.fr.

Editor: D. L. Burns

Infection and Immunity, December 2005, p. 8418-8424, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8418-8424.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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