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Infection and Immunity, December 2005, p. 8429-8432, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8429-8432.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Receptor-Mediated Clearance of Cryptococcus neoformans Capsular Polysaccharide In Vivo

Lauren E. Yauch, Michael K. Mansour,{dagger} and Stuart M. Levitz*

Departments of Medicine and Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118

Received 13 July 2005/ Returned for modification 9 August 2005/ Accepted 26 August 2005

Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant mice, none of the receptors was absolutely required for serum clearance or hepatosplenic accumulation.

* Corresponding author. Mailing address: Section of Infectious Diseases, 650 Albany St., Boston University Medical Center, Boston, MA02118. Phone: (617) 638-7904. Fax: (617) 638-7923. E-mail: slevitz{at}bu.edu.

Editor: A. Casadevall

{dagger} Present address: Department of Medicine, Massachusetts General Hospital, Gray Bigelow 740, 55 Fruit Street, Boston, MA 02114.

Infection and Immunity, December 2005, p. 8429-8432, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8429-8432.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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