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Infection and Immunity, December 2005, p. 8433-8436, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8433-8436.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Attenuation of Salmonella enterica Serovar Typhimurium by Altering Biological Functions of Murein Lipoprotein and Lipopolysaccharide

A. A. Fadl,1 J. Sha,1 G. R. Klimpel,1 J. P. Olano,2 C. L. Galindo,1 and A. K. Chopra1*

Departments of Microbiology and Immunology,1 Pathology, University of Texas Medical Branch, Galveston, Texas 77555-10702

Received 23 August 2005/ Returned for modification 17 September 2005/ Accepted 19 September 2005

We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 301 University Blvd., University of Texas Medical Branch, Galveston, TX 77555-1070. Phone: (409) 747-0578. Fax: (409) 747-6869. E-mail: achopra{at}utmb.edu.

Editor: J. T. Barbieri

Infection and Immunity, December 2005, p. 8433-8436, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8433-8436.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sha, J., Agar, S. L., Baze, W. B., Olano, J. P., Fadl, A. A., Erova, T. E., Wang, S., Foltz, S. M., Suarez, G., Motin, V. L., Chauhan, S., Klimpel, G. R., Peterson, J. W., Chopra, A. K. (2008). Braun Lipoprotein (Lpp) Contributes to Virulence of Yersiniae: Potential Role of Lpp in Inducing Bubonic and Pneumonic Plague. Infect. Immun. 76: 1390-1409 [Abstract] [Full Text]  


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