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Infection and Immunity, December 2005, p. 8437-8441, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8437-8441.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Neutralization of Tumor Necrosis Factor Alpha Suppresses Antigen-Specific Type 1 Cytokine Responses and Reverses the Inhibition of Mycobacterial Survival in Cocultures of Immune Guinea Pig T Lymphocytes and Infected Macrophages

Hyosun Cho* and David N. McMurray

Department of Microbial and Molecular Pathogenesis, The Texas A&M University System Health Science Center, College Station, Texas 77843-1114

Received 13 July 2005/ Returned for modification 27 August 2005/ Accepted 18 September 2005

Neutralization of tumor necrosis factor alpha (TNF-{alpha}) significantly down-regulated antigen-induced lymphoproliferation and the expression of interleukin-12 p40 and gamma interferon mRNA and enhanced the viability of intracellular attenuated and virulent mycobacteria in cocultures of immune T cells and macrophages obtained from Mycobacterium bovis BCG-vaccinated guinea pigs. This suggests the crucial role of TNF-{alpha} in the activation of a type 1 T-cell response against Mycobacterium tuberculosis infection.

* Corresponding author. Mailing address: Department of Microbial and Molecular Pathogenesis, The Texas A&M University System Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843-1114. Phone: (979) 845-3679. Fax: (979) 845-3479. E-mail: HScho{at}medicine.tamu.edu.

Editor: J. L. Flynn

Infection and Immunity, December 2005, p. 8437-8441, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8437-8441.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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