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Infection and Immunity, December 2005, p. 8442-8443, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8442-8443.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Eosinophils, but Not Eosinophil Peroxidase or Major Basic Protein, Are Important for Host Protection in Experimental Brugia pahangi Infection

Thirumalai Ramalingam,1 Patricia Porte,1 James Lee,2 and T. V. Rajan1*

Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut,1 Mayo Clinic, Scottsdale, Arizona2

Received 6 April 2005/ Returned for modification 31 May 2005/ Accepted 26 August 2005

The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.

* Corresponding author. Mailing address: Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3105 Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail: rajan{at}neuron.uchc.edu.

Editor: J. F. Urban, Jr.

Infection and Immunity, December 2005, p. 8442-8443, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8442-8443.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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