This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramalingam, T.
Right arrow Articles by Rajan, T. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramalingam, T.
Right arrow Articles by Rajan, T. V.

 Previous Article  |  Next Article 

Infection and Immunity, December 2005, p. 8442-8443, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8442-8443.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Eosinophils, but Not Eosinophil Peroxidase or Major Basic Protein, Are Important for Host Protection in Experimental Brugia pahangi Infection

Thirumalai Ramalingam,1 Patricia Porte,1 James Lee,2 and T. V. Rajan1*

Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut,1 Mayo Clinic, Scottsdale, Arizona2

Received 6 April 2005/ Returned for modification 31 May 2005/ Accepted 26 August 2005

The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.

* Corresponding author. Mailing address: Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3105 Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail: rajan{at}neuron.uchc.edu.

Editor: J. F. Urban, Jr.

Infection and Immunity, December 2005, p. 8442-8443, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8442-8443.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Galioto, A. M., Hess, J. A., Nolan, T. J., Schad, G. A., Lee, J. J., Abraham, D. (2006). Role of Eosinophils and Neutrophils in Innate and Adaptive Protective Immunity to Larval Strongyloides stercoralis in Mice.. Infect. Immun. 74: 5730-5738 [Abstract] [Full Text]  
  • Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J., Hoerauf, A. (2006). Lack of Eosinophil Peroxidase or Major Basic Protein Impairs Defense against Murine Filarial Infection. Infect. Immun. 74: 5236-5243 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»