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Infection and Immunity, December 2005, p. 8449-8452, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8449-8452.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Different Helicobacter hepaticus Strains with Variable Genomic Content Induce Various Degrees of Hepatitis

Samuel R. Boutin,1,2 Zeli Shen,1 Arlin B. Rogers,1 Yan Feng,1 Zhongming Ge,1 Sandy Xu,1 Torsten Sterzenbach,3 Christine Josenhans,3 David B. Schauer,1,2 Sebastian Suerbaum,3 and James G. Fox1,2*

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts,1 Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts,2 Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany3

Received 11 July 2005/ Accepted 15 September 2005

A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one of three strains of H. hepaticus: type strain Hh3B1, which contains the complete PAI, and strains HhNET and HhG, which lack all or large parts of HHGI1, respectively. Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-825C, Cambridge, MA 02139. Phone: (617) 253-1735. Fax: (617) 258-5708. E-mail: jgfox{at}mit.edu.

Editor: D. L. Burns

Infection and Immunity, December 2005, p. 8449-8452, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8449-8452.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sterzenbach, T., Lee, S. K., Brenneke, B., von Goetz, F., Schauer, D. B., Fox, J. G., Suerbaum, S., Josenhans, C. (2007). Inhibitory Effect of Enterohepatic Helicobacter hepaticus on Innate Immune Responses of Mouse Intestinal Epithelial Cells. Infect. Immun. 75: 2717-2728 [Abstract] [Full Text]  
  • Kusters, J. G., van Vliet, A. H. M., Kuipers, E. J. (2006). Pathogenesis of Helicobacter pylori Infection. Clin. Microbiol. Rev. 19: 449-490 [Abstract] [Full Text]  


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