This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boutin, S. R.
Right arrow Articles by Fox, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boutin, S. R.
Right arrow Articles by Fox, J. G.

 Previous Article  |  Next Article 

Infection and Immunity, December 2005, p. 8449-8452, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8449-8452.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Different Helicobacter hepaticus Strains with Variable Genomic Content Induce Various Degrees of Hepatitis

Samuel R. Boutin,1,2 Zeli Shen,1 Arlin B. Rogers,1 Yan Feng,1 Zhongming Ge,1 Sandy Xu,1 Torsten Sterzenbach,3 Christine Josenhans,3 David B. Schauer,1,2 Sebastian Suerbaum,3 and James G. Fox1,2*

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts,1 Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts,2 Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany3

Received 11 July 2005/ Accepted 15 September 2005

A 70-kb genomic island (HHGI1) in Helicobacter hepaticus strain ATCC 51449 is a putative pathogenicity island (PAI). To determine the in vivo relevance of this PAI, we inoculated A/JCr mice with one of three strains of H. hepaticus: type strain Hh3B1, which contains the complete PAI, and strains HhNET and HhG, which lack all or large parts of HHGI1, respectively. Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1.

* Corresponding author. Mailing address: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-825C, Cambridge, MA 02139. Phone: (617) 253-1735. Fax: (617) 258-5708. E-mail: jgfox{at}mit.edu.

Editor: D. L. Burns

Infection and Immunity, December 2005, p. 8449-8452, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8449-8452.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fox, J. G., Shen, Z., Muthupalani, S., Rogers, A. R., Kirchain, S. M., Dewhirst, F. E. (2009). Chronic Hepatitis, Hepatic Dysplasia, Fibrosis, and Biliary Hyperplasia in Hamsters Naturally Infected with a Novel Helicobacter Classified in the H. bilis Cluster. J. Clin. Microbiol. 47: 3673-3681 [Abstract] [Full Text]  
  • Sterzenbach, T., Lee, S. K., Brenneke, B., von Goetz, F., Schauer, D. B., Fox, J. G., Suerbaum, S., Josenhans, C. (2007). Inhibitory Effect of Enterohepatic Helicobacter hepaticus on Innate Immune Responses of Mouse Intestinal Epithelial Cells. Infect. Immun. 75: 2717-2728 [Abstract] [Full Text]  
  • Kusters, J. G., van Vliet, A. H. M., Kuipers, E. J. (2006). Pathogenesis of Helicobacter pylori Infection. Clin. Microbiol. Rev. 19: 449-490 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»