This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Handley, S. A.
Right arrow Articles by Miller, V. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Handley, S. A.
Right arrow Articles by Miller, V. L.

 Previous Article  |  Next Article 

Infection and Immunity, December 2005, p. 8453-8455, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8453-8455.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Yersinia enterocolitica Invasin-Dependent and Invasin-Independent Mechanisms of Systemic Dissemination

Scott A. Handley,1 Rodney D. Newberry,2 and Virginia L. Miller1,3*

Department of Molecular Microbiology,1 Department of Internal Medicine,2 Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 631103

Received 16 May 2005/ Returned for modification 29 July 2005/ Accepted 30 August 2005

We report here invasin-dependent and invasin-independent mechanisms in which the enteropathogen Yersinia enterocolitica is able to disseminate from the lumen of the small intestine to the spleen. The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes.

* Corresponding author. Mailing address: Washington University School of Medicine, Department of Molecular Microbiology, 660 S. Euclid Ave., Campus Box 8230, St. Louis, MO, 63110. Phone: (314) 286-2891. Fax: (314) 286-2896. E-mail: virginia{at}borcim.wustl.edu.

Editor: V. J. DiRita

Infection and Immunity, December 2005, p. 8453-8455, Vol. 73, No. 12
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.12.8453-8455.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Westphal, S., Lugering, A., von Wedel, J., von Eiff, C., Maaser, C., Spahn, T., Heusipp, G., Schmidt, M. A., Herbst, H., Williams, I. R., Domschke, W., Kucharzik, T. (2008). Resistance of Chemokine Receptor 6-Deficient Mice to Yersinia Enterocolitica Infection: Evidence of Defective M-Cell Formation in Vivo. Am. J. Pathol. 172: 671-680 [Abstract] [Full Text]  
  • Oellerich, M. F., Jacobi, C. A., Freund, S., Niedung, K., Bach, A., Heesemann, J., Trulzsch, K. (2007). Yersinia enterocolitica Infection of Mice Reveals Clonal Invasion and Abscess Formation. Infect. Immun. 75: 3802-3811 [Abstract] [Full Text]  
  • KuoLee, R., Zhao, X., Austin, J., Harris, G., Conlan, J. W., Chen, W. (2007). Mouse Model of Oral Infection with Virulent Type A Francisella tularensis. Infect. Immun. 75: 1651-1660 [Abstract] [Full Text]  
  • Halle, S., Bumann, D., Herbrand, H., Willer, Y., Dahne, S., Forster, R., Pabst, O. (2007). Solitary Intestinal Lymphoid Tissue Provides a Productive Port of Entry for Salmonella enterica Serovar Typhimurium. Infect. Immun. 75: 1577-1585 [Abstract] [Full Text]  
  • Wong, K.-W., Mohammadi, S., Isberg, R. R. (2006). Disruption of RhoGDI and RhoA Regulation by a Rac1 Specificity Switch Mutant. J. Biol. Chem. 281: 40379-40388 [Abstract] [Full Text]  
  • Barnes, P. D., Bergman, M. A., Mecsas, J., Isberg, R. R. (2006). Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. JEM 203: 1591-1601 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»