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Infection and Immunity, February 2005, p. 1187-1190, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1187-1190.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Defective Phagocytosis in Anaplasma phagocytophilum- Infected Neutrophils

Justin W. A. Garyu,1 Kyoung-seong Choi,1 Dennis J. Grab,2 and J. Stephen Dumler1*

Division of Medical Microbiology, Department of Pathology,1 Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland2

Received 1 September 2004/ Returned for modification 13 October 2004/ Accepted 19 October 2004

Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.

* Corresponding author. Mailing address: Department of Pathology, Division of Medical Microbiology, The Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross 624, Baltimore, MD 21205. Phone: (410) 955-8654. Fax: (443) 287-3665. E-mail: sdumler{at}jhmi.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, February 2005, p. 1187-1190, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1187-1190.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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