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Infection and Immunity, February 2005, p. 1191-1195, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1191-1195.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Distinct Leishmania braziliensis Isolates Induce Different Paces of Chemokine Expression Patterns

Maria Jania Teixeira,1,2,3 Juliana Dumet Fernandes,1,2 Clarissa Romero Teixeira,1,2 Bruno Bezerril Andrade,1,2 Margarida Lima Pompeu,3 João Santana da Silva,4 Cláudia Ida Brodskyn,1,2,5 Manoel Barral-Netto,1,2,5 and Aldina Barral1,2,5*

Centro de Pesquisas Gonçalo Moniz-Fiocruz,1 Faculdade de Medicina, Universidade Federal da Bahia-UFBA,2 Immunology Investigation Institute, Salvador,5 Núcleo de Medicina Tropical, Universidade Federal do Ceará-UFC, Fortaleza,3 Departamento de Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidad de São Paulo, Ribeirão Preto, Brazil4

Received 30 May 2004/ Returned for modification 24 September 2004/ Accepted 18 October 2004

Inflammatory events during Leishmania braziliensis infection in mice were investigated. Large lesions were directly correlated with the inflammatory reaction but not with parasite burden. Different L. braziliensis strains induce different paces of chemokine expression patterns, leading to diverse cell recruitment and differential inflammatory responses.

* Corresponding author. Mailing address: Centro de Pesquisas Gonçalo Moniz-Fiocruz-BA, 121 Rua Waldemar Falcão, Salvador, Bahia, Brazil 40295-001. Phone: 55-71-356-4320, ext. 211. Fax: 55-71-356-2593. E-mail: abarral{at}cpqgm.fiocruz.br.

Editor: A. D. O'Brien

Infection and Immunity, February 2005, p. 1191-1195, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1191-1195.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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  • Rocha, F. J. S., Schleicher, U., Mattner, J., Alber, G., Bogdan, C. (2007). Cytokines, Signaling Pathways, and Effector Molecules Required for the Control of Leishmania (Viannia) braziliensis in Mice. Infect. Immun. 75: 3823-3832 [Abstract] [Full Text]  
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