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Infection and Immunity, February 2005, p. 1196-1203, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1196-1203.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis

Vasan K. Sambandamurthy,1,2,{dagger} Steven C. Derrick,3,{dagger} Kripa V. Jalapathy,2 Bing Chen,1,2 Robert G. Russell,4 Sheldon L. Morris,3 and William R. Jacobs Jr.1,2*

Howard Hughes Medical Institute,1 Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York,2 Department of Pathology, Lombardi Cancer Center, Georgetown University, Washington, D.C.,4 Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland3

Received 6 August 2004/ Accepted 20 September 2004

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The {Delta}lysA {Delta}panCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-2865. Fax: (718) 518-0366. E-mail: jacobsw{at}hhmi.org.

Editor: A. D. O'Brien

{dagger} V. K. Sambandamurthy and S. C. Derrick contributed equally to this work.

Infection and Immunity, February 2005, p. 1196-1203, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1196-1203.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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