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Infection and Immunity, February 2005, p. 1209-1213, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1209-1213.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Peroxisome Proliferator-Activated Receptor {gamma} and Retinoid X Receptor Agonists Have Minimal Effects on the Interaction of Endothelial Cells with Plasmodium falciparum- Infected Erythrocytes

Lena Serghides{dagger} and Kevin C. Kain*

McLaughlin-Rotman Global Health Program, McLaughlin Centre for Molecular Medicine, University of Toronto, and Centre for Travel and Tropical Medicine, Toronto General Hospital, Toronto, Ontario, Canada

Received 30 July 2004/ Returned for modification 6 September 2004/ Accepted 25 October 2004

Peroxisome proliferator-activated receptor {gamma}-retinoid X receptor (PPAR{gamma}-RXR) agonists had minimal effects on the surface levels of CD36, intercellular cell adhesion molecule-1, or platelet-endothelial cell adhesion molecule-1 and had no effect on the cytoadherence of infected erythrocytes to either human umbilical vein endothelial cells or human microvascular endothelial cells or on malaria-induced interleukin-6 secretion from these cells. PPAR{gamma}-RXR agonists do not significantly modify malaria-infected erythrocyte-endothelial cell interactions in vitro.

* Corresponding author. Mailing address: Toronto General Hospital, 200 Elizabeth St. 9ES-412, Toronto, Ontario, M5G 2C4 Canada. Phone: (416) 340-3535. Fax: (416) 595-5826. E-mail: kevin.kain{at}uhn.on.ca.

Editor: W. A. Petri, Jr.

{dagger} Present address: Department of Immunology, University of Toronto, Toronto, Ontario, M5S 1A8 Canada.

Infection and Immunity, February 2005, p. 1209-1213, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1209-1213.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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