This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wing, H. J.
Right arrow Articles by Goldberg, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wing, H. J.
Right arrow Articles by Goldberg, M. B.

 Previous Article  |  Next Article 

Infection and Immunity, February 2005, p. 1217-1220, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1217-1220.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Modulation of an Outer Membrane Protease Contributes to the Virulence Defect of Shigella flexneri Strains Carrying a Mutation in the virK Locus

Helen J. Wing ,{dagger},{ddagger} Seth R. Goldman,{dagger} Shabeen Ally, and Marcia B. Goldberg*

Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts

Received 9 July 2004/ Returned for modification 16 September 2004/ Accepted 20 October 2004

The Shigella actin assembly protein IcsA is removed from the bacterial surface by the protease IcsP. We show that decreased intracellular spreading of virK::Tn10 mutants is due in part to significant increases in IcsP and IcsP-mediated cleavage of IcsA and that IcsP expression is a critical determinant of Shigella virulence.

* Corresponding author. Mailing address: Bacterial Pathogenesis Laboratories, University Park, 65 Landsdowne St., Cambridge, MA 02139. Phone: (617) 768-8740. Fax: (617) 768-8738. E-mail: mgoldberg1{at}partners.org.

Editor: J. N. Weiser

{dagger} H.J.W. and S.R.G. contributed equally to this work.

{ddagger} Present address: Department of Biological Sciences, University of Nevada-Las Vegas, Las Vegas.

Infection and Immunity, February 2005, p. 1217-1220, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1217-1220.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Novik, V., Hofreuter, D., Galan, J. E. (2009). Characterization of a Campylobacter jejuni VirK Protein Homolog as a Novel Virulence Determinant. Infect. Immun. 77: 5428-5436 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»