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Infection and Immunity, February 2005, p. 1232-1234, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1232-1234.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Age-Dependent Changes in Susceptibility of Suckling Mice to Individual Strains of Helicobacter pylori

Hiroyuki Suto,^1, Maojun Zhang,^1, and Douglas E. Berg^1,2,3*

Departments of Molecular Microbiology,¹ Medicine,² Genetics, Washington University Medical School, St. Louis, Missouri³

Received 6 August 2004/ Returned for modification 29 September 2004/ Accepted 19 October 2004

To model establishment of Helicobacter pylori infection in infants, suckling mice were inoculated with mixtures of strains that preferentially colonize different gastric regions and coexist in vivo. Characterization of H. pylori recovered 2 weeks later showed that susceptibility begins earlier for some strains than for others and that the onset of susceptibility varies among mouse lines.

Editor: A. D. O'Brien

Present address: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Present address: Institute for Communicable Disease Control and Prevention, Beijing, China.

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