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Infection and Immunity, February 2005, p. 1235-1238, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1235-1238.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Plasmodium falciparum Merozoite Surface Protein 6 Displays Multiple Targets for Naturally Occurring Antibodies That Mediate Monocyte-Dependent Parasite Killing

Subhash Singh,1 Soe Soe,1 Christian Roussilhon,1 Giampietro Corradin,2 and Pierre Druilhe1*

Bio-medical Parasitology Unit, Pasteur Institute, Paris, France,1 Institute of Biochemistry, University of Lausanne, Switzerland2

Received 27 July 2004/ Returned for modification 12 September 2004/ Accepted 19 October 2004

Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.

* Corresponding author. Mailing address: Bio-medical Parasitology Unit, Institute Pasteur 28, rue du Dr Roux, 75015 Paris, France. Phone: 0033-1-45-68-85-78. Fax: 0033-1-45-68-86-40. E-mail: druilhe{at}pasteur.fr.

Editor: W. A. Petri, Jr.

Infection and Immunity, February 2005, p. 1235-1238, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1235-1238.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Lundquist, R., Nielsen, L. K., Jafarshad, A., SoeSoe, D., Christensen, L. H., Druilhe, P., Dziegiel, M. H. (2006). Human Recombinant Antibodies against Plasmodium falciparum Merozoite Surface Protein 3 Cloned from Peripheral Blood Leukocytes of Individuals with Immunity to Malaria Demonstrate Antiparasitic Properties.. Infect. Immun. 74: 3222-3231 [Abstract] [Full Text]  


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