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Infection and Immunity, February 2005, p. 1239-1242, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1239-1242.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CaNAT1, a Heterologous Dominant Selectable Marker for Transformation of Candida albicans and Other Pathogenic Candida Species

Junqing Shen,{dagger} Weihui Guo,{dagger},{ddagger} and Julia R. Köhler*

Division of Infectious Disease, Children's Hospital, Boston, Massachusetts

Received 16 September 2004/ Accepted 8 October 2004

A dominant selectable marker for Candida albicans and other Candida species, which confers resistance to nourseothricin, was characterized. In a heterologous promoter system and a recyclable cassette, the marker efficiently permitted deletion and complementation of C. albicans genes. Neither growth nor filamentous development was affected in strains expressing this marker.

* Corresponding author. Mailing address: Division of Infectious Disease, Enders 7, Children's Hospital, 300 Longwood Ave., Boston, MA 02115. Phone: (617) 355-7621. Fax: (617) 730-0254. E-mail: julia.koehler{at}childrens.harvard.edu.

Editor: V. J. DiRita

{dagger} J.S. and W.G. contributed equally to this work.

{ddagger} Present address: Division of Endocrinology, Children's Hospital, Boston, Mass.

Infection and Immunity, February 2005, p. 1239-1242, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1239-1242.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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