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Infection and Immunity, February 2005, p. 1252-1255, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1252-1255.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mutagenesis of a Novel Gene in the prcA-prtP Protease Locus Affects Expression of Treponema denticola Membrane Complexes

Xue-lin Bian,1,{dagger} Hong-tao Wang,1 Yu Ning,1 Si Young Lee,1,2 and J. Christopher Fenno1*

Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan,1 Department of Oral Microbiology, College of Dentistry, Kangnung National University, Kangnung, South Korea2

Received 27 July 2004/ Returned for modification 20 September 2004/ Accepted 30 October 2004

A novel gene was identified in the Treponema denticola prcA-prtP protease operon. Strains with mutations in either the prcA-prtP or the msp region showed altered expression of a product(s) of the other locus. Together, these results provide information on the assembly of outer membrane complexes involved in T. denticola interaction with host cells and tissue.


* Corresponding author. Mailing address: Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078. Phone: (734) 763-3331. Fax: (734) 647-2110. E-mail: fenno{at}umich.edu.

Editor: J. T. Barbieri

{dagger} Present address: Department of Medical Microbiology and Immunology, Texas A&M University System Health Science Center, College Station, TX 77843-1114.


Infection and Immunity, February 2005, p. 1252-1255, Vol. 73, No. 2
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.2.1252-1255.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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