This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eruslanov, E. B.
Right arrow Articles by Apt, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eruslanov, E. B.
Right arrow Articles by Apt, A. S.

 Previous Article  |  Next Article 

Infection and Immunity, March 2005, p. 1744-1753, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1744-1753.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice

Evgenyi B. Eruslanov,1 Irina V. Lyadova,1 Tatiana K. Kondratieva,1 Konstantin B. Majorov,1 Ilya V. Scheglov,1 Marianna O. Orlova,1 and Alexander S. Apt1*

Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia1

Received 1 June 2004/ Returned for modification 17 August 2004/ Accepted 27 September 2004

The role of neutrophils in tuberculosis (TB) resistance and pathology is poorly understood. Neutrophil reactions are meant to target the offending pathogen but may lead to destruction of the host lung tissue, making the defending cells an enemy. Here, we show that mice of the I/St strain which are genetically susceptible to TB show an unusually high and prolonged neutrophil accumulation in their lungs after intratracheal infection. Compared to neutrophils from more resistant A/Sn mice, I/St neutrophils display an increased mobility and tissue influx, prolonged lifespan, low expression of the CD95 (Fas) apoptotic receptor, relative resistance to apoptosis, and an increased phagocytic capacity for mycobacteria. Segregation genetic analysis in (I/St x A/Sn)F2 hybrids indicates that the alleles of I/St origin at the chromosome 3 and 17 quantitative trait loci which are involved in the control of TB severity also determine a high level of neutrophil influx. These features, along with the poor ability of neutrophils to restrict mycobacterial growth compared to that of lung macrophages, indicate that the prevalence of neutrophils in TB inflammation contributes to the development of pathology, rather than protection of the host, and that neutrophils may play the role of a "Trojan horse" for mycobacteria.

* Corresponding author. Mailing address: Laboratory for Immunogenetics, Central Institute for Tuberculosis, Yauza Alley 2, Moscow 107564, Russia. Phone: (7095) 268 78 10. Fax: (7095) 963 80 00. E-mail: asapt{at}aha.ru.

Editor: A. D. O'Brien

Infection and Immunity, March 2005, p. 1744-1753, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1744-1753.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pichugin, A. V., Yan, B.-S., Sloutsky, A., Kobzik, L., Kramnik, I. (2009). Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts. Am. J. Pathol. 174: 2190-2201 [Abstract] [Full Text]  
  • Locke, L. W., Chordia, M. D., Zhang, Y., Kundu, B., Kennedy, D., Landseadel, J., Xiao, L., Fairchild, K. D., Berr, S. S., Linden, J., Pan, D. (2009). A Novel Neutrophil-Specific PET Imaging Agent: cFLFLFK-PEG-64Cu. JNM 50: 790-797 [Abstract] [Full Text]  
  • Maglione, P. J., Xu, J., Casadevall, A., Chan, J. (2008). Fc{gamma} Receptors Regulate Immune Activation and Susceptibility during Mycobacterium tuberculosis Infection. J. Immunol. 180: 3329-3338 [Abstract] [Full Text]  
  • Kondratieva, E. V., Evstifeev, V. V., Kondratieva, T. K., Petrovskaya, S. N., Pichugin, A. V., Rubakova, E. I., Averbakh, M. M. Jr., Apt, A. S. (2007). I/St Mice Hypersusceptible to Mycobacterium tuberculosis Are Resistant to M. avium. Infect. Immun. 75: 4762-4768 [Abstract] [Full Text]  
  • Maglione, P. J., Xu, J., Chan, J. (2007). B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis. J. Immunol. 178: 7222-7234 [Abstract] [Full Text]  
  • Hogan, L. H., Heninger, E., Elsner, R. A., Vonderheid, H. A., Hulseberg, P., Co, D., Sandor, M. (2007). Requirements for CD4+ T cell levels in acute Mycobacterium bovis strain bacille Calmette Guerin (BCG)-induced granulomas differ for optimal mycobacterial control versus granuloma formation. Int Immunol 19: 627-633 [Abstract] [Full Text]  
  • Tan, B. H., Meinken, C., Bastian, M., Bruns, H., Legaspi, A., Ochoa, M. T., Krutzik, S. R., Bloom, B. R., Ganz, T., Modlin, R. L., Stenger, S. (2006). Macrophages Acquire Neutrophil Granules for Antimicrobial Activity against Intracellular Pathogens. J. Immunol. 177: 1864-1871 [Abstract] [Full Text]  
  • Keller, C., Hoffmann, R., Lang, R., Brandau, S., Hermann, C., Ehlers, S. (2006). Genetically Determined Susceptibility to Tuberculosis in Mice Causally Involves Accelerated and Enhanced Recruitment of Granulocytes. Infect. Immun. 74: 4295-4309 [Abstract] [Full Text]  
  • Martens, R. J., Cohen, N. D., Jones, S. L., Moore, T. A., Edwards, J. F. (2005). Protective Role of Neutrophils in Mice Experimentally Infected with Rhodococcus equi. Infect. Immun. 73: 7040-7042 [Abstract] [Full Text]  
  • Majorov, K. B., Eruslanov, E. B., Rubakova, E. I., Kondratieva, T. K., Apt, A. S. (2005). Analysis of Cellular Phenotypes That Mediate Genetic Resistance to Tuberculosis Using a Radiation Bone Marrow Chimera Approach. Infect. Immun. 73: 6174-6178 [Abstract] [Full Text]  
  • Abadie, V., Badell, E., Douillard, P., Ensergueix, D., Leenen, P. J. M., Tanguy, M., Fiette, L., Saeland, S., Gicquel, B., Winter, N. (2005). Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood 106: 1843-1850 [Abstract] [Full Text]  
  • Kaufmann, S. H.E., Cole, S. T., Mizrahi, V., Rubin, E., Nathan, C. (2005). Mycobacterium tuberculosis and the host response. JEM 201: 1693-1697 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»