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Infection and Immunity, March 2005, p. 1847-1851, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1847-1851.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Bacterial and Host Factors Implicated in Nasal Carriage of Methicillin-Resistant Staphylococcus aureus in Mice

Bruno González-Zorn,1,{dagger} Jose P. M. Senna,1,{ddagger} Laurence Fiette,2 Spencer Shorte,3 Aurélie Testard,1 Michel Chignard,4 Patrice Courvalin,1 and Catherine Grillot-Courvalin1*

Unité des Agents Antibactériens,1 Unité de Recherche et d'Expertise en Histotechnologie et Pathologie,2 Plate-forme d'Imagerie Dynamique,3 Unité de Défense Innée et Inflammation, INSERM E336, Institut Pasteur, Paris, France4

Received 22 September 2004/ Returned for modification 17 October 2004/ Accepted 4 November 2004

Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice.

* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: (33) 1 45 68 83 20. Fax: (33) 1 45 68 83 19. E-mail: ccourval{at}pasteur.fr.

Editor: F. C. Fang

{dagger} Present address: Departemento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.

{ddagger} Present address: Laboratorio de Tecnologia Recombinante, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Infection and Immunity, March 2005, p. 1847-1851, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1847-1851.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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