This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yao, Y. Articles by Otto, M. Search for Related Content PubMed PubMed Citation Articles by Yao, Y. Articles by Otto, M.

 Previous Article  |  Next Article 

Infection and Immunity, March 2005, p. 1856-1860, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1856-1860.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics

Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana,¹ Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China²

Received 27 July 2004/ Returned for modification 10 September 2004/ Accepted 17 October 2004

Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.

Editor: F. C. Fang

This article has been cited by other articles:

• Handke, L. D., Rogers, K. L., Olson, M. E., Somerville, G. A., Jerrells, T. J., Rupp, M. E., Dunman, P. M., Fey, P. D. (2008). Staphylococcus epidermidis saeR Is an Effector of Anaerobic Growth and a Mediator of Acute Inflammation. Infect. Immun. 76: 141-152 [Abstract] [Full Text]  
• Citron, D. M., Goldstein, E. J. C., Merriam, C. V., Lipsky, B. A., Abramson, M. A. (2007). Bacteriology of Moderate-to-Severe Diabetic Foot Infections and In Vitro Activity of Antimicrobial Agents. J. Clin. Microbiol. 45: 2819-2828 [Abstract] [Full Text]  
• Daniel, A., Bonnen, P. E., Fischetti, V. A. (2007). First Complete Genome Sequence of Two Staphylococcus epidermidis Bacteriophages. J. Bacteriol. 189: 2086-2100 [Abstract] [Full Text]  
• Sarkar, S. F., Gordon, J. S., Martin, G. B., Guttman, D. S. (2006). Comparative Genomics of Host-Specific Virulence in Pseudomonas syringae. Genetics 174: 1041-1056 [Abstract] [Full Text]  
• Terekhova, D., Iyer, R., Wormser, G. P., Schwartz, I. (2006). Comparative Genome Hybridization Reveals Substantial Variation among Clinical Isolates of Borrelia burgdorferi Sensu Stricto with Different Pathogenic Properties.. J. Bacteriol. 188: 6124-6134 [Abstract] [Full Text]  
• Yao, Y., Xie, Y., Kim, K. S. (2006). Genomic Comparison of Escherichia coli K1 Strains Isolated from the Cerebrospinal Fluid of Patients with Meningitis. Infect. Immun. 74: 2196-2206 [Abstract] [Full Text]  
• MacFarlane, R. C., Singh, U. (2006). Identification of Differentially Expressed Genes in Virulent and Nonvirulent Entamoeba Species: Potential Implications for Amebic Pathogenesis. Infect. Immun. 74: 340-351 [Abstract] [Full Text]