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Infection and Immunity, March 2005, p. 1856-1860, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1856-1860.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Factors Characterizing Staphylococcus epidermidis Invasiveness Determined by Comparative Genomics

Yufeng Yao,1 Daniel E. Sturdevant,1 Amer Villaruz,1 Lin Xu,2 Qian Gao,2 and Michael Otto1*

Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana,1 Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China2

Received 27 July 2004/ Returned for modification 10 September 2004/ Accepted 17 October 2004

Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.

* Corresponding author. Mailing address: 903 S. 4th St., Hamilton, MT 59840. Phone: (406) 363-9283. Fax: (406) 375-9677. E-mail: motto{at}niaid.nih.gov.

Editor: F. C. Fang

Infection and Immunity, March 2005, p. 1856-1860, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1856-1860.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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