This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An authors' corrections has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dong, F.
Right arrow Articles by Zhong, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dong, F.
Right arrow Articles by Zhong, G.

 Previous Article  |  Next Article 

Infection and Immunity, March 2005, p. 1861-1864, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1861-1864.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Degradation of the Proapoptotic Proteins Bik, Puma, and Bim with Bcl-2 Domain 3 Homology in Chlamydia trachomatis-Infected Cells

Feng Dong,1 Mustak Pirbhai,1 Yangming Xiao,1 Youmin Zhong,1 Yimou Wu,2 and Guangming Zhong1*

Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas,1 Department of Microbiology, Nanhua University, Hengyang, Hunan, China2

Received 17 September 2004/ Returned for modification 21 September 2004/ Accepted 4 November 2004

We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and the inhibition of Bax and Bak activation. We now report that C. trachomatis infection leads to degradation of Bik, Puma, and Bim, three upstream proapoptotic BH3-only proteins of the Bcl-2 family that can transmit death signals to mitochondria by inhibiting the Bcl-2 antiapoptotic proteins and/or activating the Bcl-2 proapoptotic members, such as Bax and Bak. This observation has provided new information on the chlamydial antiapoptosis mechanisms.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229. Phone: (210) 567-1169. Fax: (210) 567-0293. E-mail: zhongg{at}uthscsa.edu.

Editor: D. L. Burns

Infection and Immunity, March 2005, p. 1861-1864, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1861-1864.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • de la Torre, E., Mulla, M. J., Yu, A. G., Lee, S.-J., Kavathas, P. B., Abrahams, V. M. (2009). Chlamydia trachomatis Infection Modulates Trophoblast Cytokine/Chemokine Production. J. Immunol. 182: 3735-3745 [Abstract] [Full Text]  
  • Kleba, B., Stephens, R. S. (2008). Chlamydial Effector Proteins Localized to the Host Cell Cytoplasmic Compartment. Infect. Immun. 76: 4842-4850 [Abstract] [Full Text]  
  • Li, Z., Chen, D., Zhong, Y., Wang, S., Zhong, G. (2008). The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells. Infect. Immun. 76: 3415-3428 [Abstract] [Full Text]  
  • Li, Z., Chen, C., Chen, D., Wu, Y., Zhong, Y., Zhong, G. (2008). Characterization of Fifty Putative Inclusion Membrane Proteins Encoded in the Chlamydia trachomatis Genome. Infect. Immun. 76: 2746-2757 [Abstract] [Full Text]  
  • Sun, J., Kintner, J., Schoborg, R. V. (2008). The host adherens junction molecule nectin-1 is downregulated in Chlamydia trachomatis-infected genital epithelial cells. Microbiology 154: 1290-1299 [Abstract] [Full Text]  
  • Cheng, W., Shivshankar, P., Li, Z., Chen, L., Yeh, I-T., Zhong, G. (2008). Caspase-1 Contributes to Chlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection. Infect. Immun. 76: 515-522 [Abstract] [Full Text]  
  • Luhrmann, A., Roy, C. R. (2007). Coxiella burnetii Inhibits Activation of Host Cell Apoptosis through a Mechanism That Involves Preventing Cytochrome c Release from Mitochondria. Infect. Immun. 75: 5282-5289 [Abstract] [Full Text]  
  • Voth, D. E., Howe, D., Heinzen, R. A. (2007). Coxiella burnetii Inhibits Apoptosis in Human THP-1 Cells and Monkey Primary Alveolar Macrophages. Infect. Immun. 75: 4263-4271 [Abstract] [Full Text]  
  • Clark, C. S., Maurelli, A. T. (2007). Shigella flexneri Inhibits Staurosporine-Induced Apoptosis in Epithelial Cells. Infect. Immun. 75: 2531-2539 [Abstract] [Full Text]  
  • Shimazu, T., Degenhardt, K., Nur-E-Kamal, A., Zhang, J., Yoshida, T., Zhang, Y., Mathew, R., White, E., Inouye, M. (2007). NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev. 21: 929-941 [Abstract] [Full Text]  
  • Banga, S., Gao, P., Shen, X., Fiscus, V., Zong, W.-X., Chen, L., Luo, Z.-Q. (2007). Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. Proc. Natl. Acad. Sci. USA 104: 5121-5126 [Abstract] [Full Text]  
  • Flores, R., Luo, J., Chen, D., Sturgeon, G., Shivshankar, P., Zhong, Y., Zhong, G. (2007). Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae. Microbiology 153: 777-786 [Abstract] [Full Text]  
  • Pirbhai, M., Dong, F., Zhong, Y., Pan, K. Z., Zhong, G. (2006). The Secreted Protease Factor CPAF Is Responsible for Degrading Pro-apoptotic BH3-only Proteins in Chlamydia trachomatis-infected Cells. J. Biol. Chem. 281: 31495-31501 [Abstract] [Full Text]  
  • Balsara, Z. R., Misaghi, S., Lafave, J. N., Starnbach, M. N. (2006). Chlamydia trachomatis Infection Induces Cleavage of the Mitotic Cyclin B1.. Infect. Immun. 74: 5602-5608 [Abstract] [Full Text]  
  • Chen, C., Chen, D., Sharma, J., Cheng, W., Zhong, Y., Liu, K., Jensen, J., Shain, R., Arulanandam, B., Zhong, G. (2006). The Hypothetical Protein CT813 Is Localized in the Chlamydia trachomatis Inclusion Membrane and Is Immunogenic in Women Urogenitally Infected with C. trachomatis.. Infect. Immun. 74: 4826-4840 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»