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Infection and Immunity, March 2005, p. 1879-1885, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1879-1885.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

GeneChip Analyses of Global Transcriptional Responses of Murine Macrophages to the Lethal Toxin of Bacillus anthracis

Jason E. Comer,1 Cristi L. Galindo,2 Ashok K. Chopra,2*,{dagger} and Johnny W. Peterson2*,{dagger}

Departments of Experimental Pathology,1 Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas2

Received 10 September 2004/ Returned for modification 11 November 2004/ Accepted 16 November 2004

We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical Research Building, 301 University Blvd., Galveston, TX 77555-1070. For Ashok K. Chopra: Phone: (409) 747-0578. Fax: (409) 747-6869. E-mail: achopra{at}utmb.edu. For Johnny W. Peterson: Phone: (409) 772-4910. Fax: (409) 747-6869. E-mail: jpeterso{at}utmb.edu.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical Research Building, 301 University Blvd., Galveston, TX 77555-1070. For Ashok K. Chopra: Phone: (409) 747-0578. Fax: (409) 747-6869. E-mail: achopra{at}utmb.edu. For Johnny W. Peterson: Phone: (409) 772-4910. Fax: (409) 747-6869. E-mail: jpeterso{at}utmb.edu.

Editor: J. T. Barbieri

{dagger} A.K.C. and J.W.P. contributed equally to the manuscript.

Infection and Immunity, March 2005, p. 1879-1885, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1879-1885.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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