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Infection and Immunity, March 2005, p. 1886-1889, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1886-1889.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Glutathione and Nitrosoglutathione in Macrophage Defense against Mycobacterium tuberculosis

Vishwanath Venketaraman,1,2,3,4* Yaswant K. Dayaram,2,3,4 Meliza T. Talaue,2,3,4 and Nancy D. Connell1,2,3,4

Department of Medicine,1 Department of Microbiology and Molecular Genetics,2 New Jersey Medical School National Tuberculosis Center,3 Center for Emerging and Re-emerging Pathogens, UMDNJ-New Jersey Medical School, Newark, New Jersey4

Received 26 August 2004/ Returned for modification 15 October 2004/ Accepted 5 November 2004

We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, UMDNJ-ICPH, 225 Warren St., Newark, NJ 07103. Phone: (973) 972-4483, ext. 28963. Fax: (973) 972-8981. E-mail: venketvi{at}umdnj.edu.

Editor: J. L. Flynn

Infection and Immunity, March 2005, p. 1886-1889, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1886-1889.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Gaston, B., Singel, D., Doctor, A., Stamler, J. S. (2006). S-Nitrosothiol Signaling in Respiratory Biology. Am. J. Respir. Crit. Care Med. 173: 1186-1193 [Abstract] [Full Text]  
  • Dayaram, Y. K., Talaue, M. T., Connell, N. D., Venketaraman, V. (2006). Characterization of a Glutathione Metabolic Mutant of Mycobacterium tuberculosis and Its Resistance to Glutathione and Nitrosoglutathione. J. Bacteriol. 188: 1364-1372 [Abstract] [Full Text]  


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