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Infection and Immunity, March 2005, p. 1895-1897, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1895-1897.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genetic Vaccination against Murine Cysticercosis by Using a Plasmid Vector Carrying Taenia solium Paramyosin

Carlos F. Solís,1 Pedro Ostoa-Saloma,1 Verónica H. Lugo-Martínez,1 Stephen Albert Johnston,2 and Juan Pedro Laclette1*

Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico,1 Center for Biomedical Inventions, Department of Internal Medicine, University of Texas-Southwestern Medical Center, Dallas, Texas2

Received 23 October 2004/ Returned for modification 2 November 2004/ Accepted 22 November 2004

A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used.

* Corresponding author. Mailing address: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, Ciudad Universitaria, C.P. 04510, México D.F., Mexico. Phone: (525) 5622-3862. Fax:. (525) 5550-6447. E-mail: laclette{at}servidor.unam.mx.

Editor: W. A. Petri, Jr.

Infection and Immunity, March 2005, p. 1895-1897, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1895-1897.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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