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Infection and Immunity, March 2005, p. 1903-1905, Vol. 73, No. 3
0019-9567/05/$08.00+0     doi:10.1128/IAI.73.3.1903-1905.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mice Fed Lipid-Encapsulated Mycobacterium bovis BCG Are Protected against Aerosol Challenge with Mycobacterium tuberculosis

Frank E. Aldwell,^1* Lise Brandt,^2, Clare Fitzpatrick,¹ and Ian M. Orme²

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand,¹ Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado²

Received 22 September 2004/ Returned for modification 2 November 2004/ Accepted 11 November 2004

Mice that consumed a single dose of 10⁷ lipid-encapsulated Mycobacterium bovis BCG bacilli showed significant pulmonary and systemic protection against aerosol challenge with M. tuberculosis H37Rv. As an extension of previous challenge studies with virulent strains of M. bovis, this report describes a reduction in M. tuberculosis infection in mice vaccinated orally with lipid-encapculated BCG comparable to that observed in mice vaccinated subcutaneously with BCG. These results are consistent with the induction of tuberculin-specific cell-mediated immune responses.

Editor: W. A. Petri, Jr.

Present address: KLIFO A/S, Copenhagen Science Park, Symbion, 2100 Copenhagen OE, Denmark.

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